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Approvals for Use of Radioactive Materials

Approval for the use of radioactive materials is given by the Radiation Safety Committee for a period of one year, and is reviewed annually. Approval may be obtained by submitting a brief application describing the requested material and quantity to be used, the location, individuals who will handle the material, the training and experience of the applicant, the training of workers, the protective equipment to be used, if any, monitoring equipment, a brief description of experimental procedures with emphasis on potential safety concerns, and waste disposal information. Applicants must have faculty status, assistant professor or greater, experienced in the use of radioactive materials and must be trained by the ORCBS prior to approval. The application will be reviewed by RSC members, wherein approval may be granted.

The RSC may require additional conditions under which the use of the material must be conducted. The approved principal investigator may then order, receive and use the requested materials, but must do so according to the statements and representations made in the application, and any conditions set forth by the safety committee and all applicable local, state and federal laws, regulations and license conditions. Violations or infractions of these conditions may be cause for suspension or termination of the approval to receive and use radioisotopes.

For most applications to use radioactive materials, interim approval may be given by the Radiation Safety Officer (RSO) until the Radiation Safety Committee gives final approval. This precludes a long waiting period for approval. Principal investigators who are currently approved and have a good safety record may be given verbal interim approval to initiate a new use, except for work that involves a significantly higher risk. Applications for new principal investigators must be approved directly by the Radiation Safety Committee, regardless of previous approvals at other institutions.

New applications are required for the use of a new radionuclide, for a change in experimental procedures which have an impact on safety, a change in chemical or physical form of a material previously approved, and for substantial increases in the quantity. Amendments to current approvals are given for slight increases in quantity or moderate changes in chemical form, and may be obtained by submitting a short memo stating the desired change and the reason for the change, referencing to the original approved application to be amended. Applications for approval or amendments should be directed to the MSU Radiation Safety Officer.

Responsibilities of the Principal Investigator

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